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Programma per Giovedì 30 settembre
Ore 13.00-15.00

Monitoring environmental genotoxicants using bioindicators and biomarkers (sala stampa)
(Organizers: C. Bolognesi and A. Buschini)

Monitoring drinking water quality using bioindicators
» Studies on the formation of mutagens in disinfected waters
S. Monarca (Univ. di Perugia)
Experiments:
» In situ experiments using plants
D. Feretti (Univ. di Brescia)
» In situ experiments using fish
B. Gustavino (Univ. di Roma "Tor Vergata")
» In situ experiments using molluscs
A. Buschini (Univ. di Parma)
» Bioindicators in monitoring haven wreck areas
C. Bolognesi (Ist. Nazionale Ricerca sul Cancro, Genova)
» Transplanted mussels in harbour areas biomonitoring
G. Frenzilli (Univ. di Pisa)
» Bioindicators in the Venice lagoon
P. Venier (Univ. di Padova)

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Protein toxicity (sala 1000b)
(Organizers: A. Poletti and R. Sitia)

Toxic conformations
» Investigation of protein aggregation under conditions in which the protein is initially native
F. Chiti (Univ. di Firenze)
» Neurotoxicity of the recombinant prion protein fragment 90-231 in SH-SY5Y cells is dependent on its conversion into a β-structured-isoform
T. Florio (DOBIG, Univ. di Genova)

Are aggregates toxic?
» Toxicity of aggregates of non-pathologic proteins: new themes in protein folding, disease and evolution
M. Stefani (Univ. di Firenze)
» The role of protein aggregation in neurodegeneration
G. Forloni (Ist. M. Negri, Milano)
» Mechanism of cytoplasmic inclusions formation in Spinal and Bulbar Muscular Atrophy
P. Rusmini (CEND-Univ. di Milano)

Downstream mechanisms
» In vivo phenotypic effects of ataxin-1 expanded polyglutamine interrupted by histidines
C. Jodice (Univ. di Roma "Tor Vergata")
» The cytosolic domain of APP interacts with the Apoptosis Inducing Factor (AIF)
J. Rosati (IBPM CNR, Univ. di Roma "La Sapienza")

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Regulation of cell movement (sala belvedere)
(Organizer: G. Berton)

» Up and down small GTPases: signaling to actin dynamics
G. Scita (Europ. Inst. Oncology, Milano)
» Role of p27kip1 in ECM-dependent cell motility
G. Baldassarre (CRO, Pordenone)
» Role of p140Cap (Cas-associated protein) in epithelial cell motility and cell-cell contact organisation
P. Di Stefano (Univ. di Torino)
» Rap1 acts as a "traffic light" molecule at the crossroad between cadherin and integrin functions
F. Balzac (Univ. di Torino)
» Cell adhesion and motility of C2C12 murine myoblasts are regulated by S1P through distinct S1P receptors
E. Meacci (Ist. Interuniversitario di Miologia, Firenze)
» The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization
A. Baruzzi (Univ. di Verona)
» Studio del ruolo del canale di potassio HERG nella regolazione del movimento cellulare
E. Cilia (Univ. di Firenze)

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Translational repression by microRNAs: new ways of channelling cell fate (sala meeting)
(Organizer: G. Rainaldi)

» Regulation of microRNA expression in human cells and analysis of their functions
I. Bozzoni (Univ. di Roma "La Sapienza")
» Heart, myocardial infarction and mesoangioblasts
D. Galli (Stem Cell Research Institute, Dibit, HSR, Milano)
» Search and testing of VEGF-related miRNAs
L. Poliseno (IFC, CNR, Pisa)
» The molecular basis of skeletal myoblast diversification
S. Biressi (Stem Cell Research Institute, Dibit, HSR, Milano)
» Cell fate specification during Xenopus retinal development
F. Cremisi (Univ. di Pisa)

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Epigenetics (sala 100)
(Organizers: L. Chiariotti and E. Avvedimento)

Round table
» Epigenetics and transcription
» Epigenetics and DNA repair
Coordinators: N. Landsberger, V.E. Avvedimento, L. Chiariotti
Sono invitati a partecipare tutti i gruppi di ricerca interessati

Short communications
» Identification of genes silenced by epigenetic mechanisms in acute myeloid leukemia
F.P. Di Giorgio (IRBM, Roma)
» Microdeletions in the human H19 DMR result in loss of IGF2 imprinting and Beckwith-Wiedemann syndrome
A. Sparago (Seconda Univ. di Napoli)
» In vivo studies of the HST family SIR proteins in S. cerevisiae
F.R. Mariotti (Univ. di Roma "La Sapienza")
» Functional characterization of MBD proteins in Arabidopsis
F. Scebba (Univ. di Pisa)

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Redox signaling in apoptosis and survival pathways (sala 1000a)
(Organizers: L. Ghibelli and A. Leone)

» Effects of thyroid hormones hepatocyte ROS production during embryonic development
S. Spagnuolo (Univ. di Roma "La Sapienza")
» 5-lipoxygenase mediates peroxide production and apoptosis resistance in EBV-converted B lymphoma cell lines
C. Belfiore (Univ. della Tuscia, Viterbo)
» MRP1, an ABC transporter involved in HMGB1 exocytosis
E. Latorre (Univ. Vita-Salute San Raffaele, Milano)
» Redox alterations as the mechanism for Bax translocation
M. D'Alessio (Univ. di Roma "Tor Vergata")
» Different fates of intracellular glutathione determine different apoptotic morphologies
M. De Nicola (Univ. di Roma "Tor Vergata")
» The purinergic receptor P2X as a modulator of mitochondrial physiology and apoptosis
M.G. Callegari (Univ. di Ferrara)
» Stress cell defense pathways: Ca2+ flux paralysis due to glycolytic flux blocking via ADP-ribosylation of GAPDH
C. Cerella (Univ. di Roma "Tor Vergata")
»Glutathione depletion upregulates Bcl-2 in BSO-resistant cells synthase
M. D'Alessio (Univ. di Roma "Tor Vergata")
» Involvement of ascorbate peroxidase in the control of cellular redox state during oxidative stress and cell death in plants
M.C. de Pinto (Univ. di Bari)

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