3rd International Workshop on Tumor Evolution
- 30 Jan 2020
Discovering and Targeting Therapeutic vulnerabilities in the tumor microenvironment.
Rome, April 7-8, 2020
IRCCS Regina Elena National Cancer Institute
Multimedia Congress Center,
Via Fermo Ognibene 23, Rome.
It is now widely accepted that the tumor microenvironment plays a critical role in tumor progression and metastasis as well as in the development of therapeutic resistance. Understanding the complex, dynamic bidirectional interaction between cancer cells and their microenvironment is currently under intense investigation. Recent studies suggest that tumor-promoting immune cells also establish pre-metastatic niches which suppress anti-tumor immunity while promoting disseminated tumor cell survival. This indicates that malignant cancer cells induce a dynamic stromal reaction, which restrains and promotes tumor progression.
It is currently unknown how the stromal equilibrium is established and how the ratios of different stromal cell types affect tumor progression and response to therapy.
This workshop will bring together an outstanding faculty of translational and clinical oncologists who will debate the following issues 1) the molecular understanding of the reciprocal interaction between tumor cells and their microenvironment; 2) the identification of factors that influence the cross-talk between tumor and infiltrated cells; 3) the balance between anti-tumor immunity and immunosuppression; 4) novel therapeutic approaches.